Prostaglandin release by normal and osteomyelitic human bones

D. Plotquin, S. Dekel, S. Katz, A. Danon

Research output: Contribution to journalArticlepeer-review

Abstract

The release of prostaglandin E (PGE) and prostacyclin (as 6-keto PGF) by human osteomyelitic bone, compared with normal (control) bone, incubated in vitro was evaluated. Prostacyclin was the main arachidonic acid metabolite released by normal human bone, and similar quantities were released by osteomyelitic bone. However, PGE production was 5-30-fold higher in osteomyelitic bone, compared with control, thus becoming the major prostanoid in this disease. It is concluded that PGE production is probably involved in the inflammatory and/or bone resorption processes that occur in osteomyelitis.

Original languageEnglish
Pages (from-to)13-15
Number of pages3
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume43
Issue number1
DOIs
StatePublished - May 1991
Externally publishedYes

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