TY - JOUR
T1 - Prostaglandin E2 and protein levels in rabbit aqueous humor following ND:YAG laser iridotomy
AU - Rosner, M.
AU - Gelerstein, S.
AU - Weissman, C.
AU - Naveh, N.
PY - 1988
Y1 - 1988
N2 - Prostaglandin E2 (PGE2) and protein levels were measured in the aqueous humor of rabbits' eyes subjected to iridotomy with the neodymium:YAG laser. Following irradiation, PGE2 levels were elevated to the highest elevation of 20.0 ± 7.7 ng/ml (mean ± SD) at 30 minutes as compard to control levels of 0.625 ± 0.075 ng/ml. PGE2 concentrations progressively decreased, however, after 8 hours they remained high and did not resume control levels. Protein levels in the aqueous humor of ND:YAG irradiated eyes reached peak levels at 30 minutes to 7.8 ± 2.2 mg/ml compared to control level of 1.3 ± 0.4 mg/ml. A progressive decrease in protein levels was observed after peak time, but they were still above control levels, at 8 hours. Our study demonstrated that ND:YAG irradiation of the iris involves an immediate increase in PGE2 aqueous levels associated with a blood aqueous barrier disruption and augmented aqueous protein levels.
AB - Prostaglandin E2 (PGE2) and protein levels were measured in the aqueous humor of rabbits' eyes subjected to iridotomy with the neodymium:YAG laser. Following irradiation, PGE2 levels were elevated to the highest elevation of 20.0 ± 7.7 ng/ml (mean ± SD) at 30 minutes as compard to control levels of 0.625 ± 0.075 ng/ml. PGE2 concentrations progressively decreased, however, after 8 hours they remained high and did not resume control levels. Protein levels in the aqueous humor of ND:YAG irradiated eyes reached peak levels at 30 minutes to 7.8 ± 2.2 mg/ml compared to control level of 1.3 ± 0.4 mg/ml. A progressive decrease in protein levels was observed after peak time, but they were still above control levels, at 8 hours. Our study demonstrated that ND:YAG irradiation of the iris involves an immediate increase in PGE2 aqueous levels associated with a blood aqueous barrier disruption and augmented aqueous protein levels.
UR - http://www.scopus.com/inward/record.url?scp=0023818001&partnerID=8YFLogxK
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AN - SCOPUS:0023818001
SN - 0277-9382
VL - 11
SP - 50
EP - 52
JO - Metabolic, Pediatric and Systemic Ophthalmology
JF - Metabolic, Pediatric and Systemic Ophthalmology
IS - 1-2
ER -