TY - JOUR
T1 - Prospective evaluation of liver function tests in patients treated with aminoglycosides
AU - Mor, F.
AU - Leibovici, L.
AU - Cohen, O.
AU - Wysenbeek, A. J.
PY - 1990
Y1 - 1990
N2 - We investigated the relationship between therapy with aminoglycoside antibiotics and alterations in serum liver enzymes and bilirubin. One hundred fourteen patients treated with aminoglycosides and 96 treated with other antibiotics were assessed prospectively during eight days. No elevation in serum alanine aminotransferase, lactic dehydrogenase, or bilirubin was detected in the aminoglycoside and control groups. Alkaline phosphatase increased significantly in the aminoglycoside group (average elevation of 28 ± 16 units/L on day 6), but no patient had an elevation greater than twice the upper limit of the normal range. We conclude that the abnormality in liver enzymes during aminoglycoside therapy is a mild elevation in alkaline phosphatase, probably with no clinical significance.
AB - We investigated the relationship between therapy with aminoglycoside antibiotics and alterations in serum liver enzymes and bilirubin. One hundred fourteen patients treated with aminoglycosides and 96 treated with other antibiotics were assessed prospectively during eight days. No elevation in serum alanine aminotransferase, lactic dehydrogenase, or bilirubin was detected in the aminoglycoside and control groups. Alkaline phosphatase increased significantly in the aminoglycoside group (average elevation of 28 ± 16 units/L on day 6), but no patient had an elevation greater than twice the upper limit of the normal range. We conclude that the abnormality in liver enzymes during aminoglycoside therapy is a mild elevation in alkaline phosphatase, probably with no clinical significance.
UR - http://www.scopus.com/inward/record.url?scp=0025232648&partnerID=8YFLogxK
U2 - 10.1177/106002809002400203
DO - 10.1177/106002809002400203
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C2 - 2309507
AN - SCOPUS:0025232648
SN - 1042-9611
VL - 24
SP - 135
EP - 137
JO - DICP, Annals of Pharmacotherapy
JF - DICP, Annals of Pharmacotherapy
IS - 2
ER -