Prophylactic oophorectomy in premenopausal women with stage II breast carcinoma

H. Kashtan, S. Birkenfeld*, P. Rath, H. J. Brenner, M. Krispin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Prophylactic oophorectomy, as an additional treatment for stage II breast cancer, is controversial. In a retrospective study, a group of 37 premenopausal women with stage II infiltrating duct carcinoma and one to three positive axillary lymph node involvement after modified radical mastectomy and bilateral oophorectomy were compared to a matched group of 34 women treated by modified radical mastectomy only. Prophylactic oophorectomy prolonged the disease free interval significantly as compared to the control group. However, it did not prolong survival. This raises the question whether the prolongation of survival achieved by late oophorectomy in women with advanced breast cancer is preferable to an improvement in quality of life resulting from longer disease free intervals.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalJournal of Surgical Oncology
Issue number3
StatePublished - Mar 1986
Externally publishedYes


  • breast cancer
  • disease free intervals
  • premenopausal
  • prophylactic oophorectomy


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