Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Merav A. Ben-David; Benjamin W. Corn; Ella Evron; Hadassah Goldberg; Raphael M. Pfeffer; Roxoliana Abdah-Bortnyak; Dianna Matceyevsky; Yuliana Weinstein; Orit Golan; Miri Sklair-Levy

doi:10.1016/j.breast.2019.10.011

Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Merav A. Ben-David
, Benjamin W. Corn^*
, Ella Evron
, Hadassah Goldberg
, Raphael M. Pfeffer
, Roxoliana Abdah-Bortnyak
, Dianna Matceyevsky
, Yuliana Weinstein
, Orit Golan
, Miri Sklair-Levy

^*Corresponding author for this work

Sheba Medical Center at Tel Hashomer
Shaare Zedek Medical Center
Hebrew University of Jerusalem
Oncology
Western Galilee Medical Center of Nahariya
Assuta Medical Center
Technion-Israel Institute of Technology
Tel Aviv Sourasky Medical Center

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Breast
Volume	49
DOIs	https://doi.org/10.1016/j.breast.2019.10.011
State	Published - Feb 2020

Funding

Funders	Funder number
Israel Cancer Association	C-20190082

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BPE
BRCA
Breast cancer
Prophylactic breast irradiation

Access to Document

10.1016/j.breast.2019.10.011

Cite this

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title = "Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis",

abstract = "Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.",

keywords = "BPE, BRCA, Breast cancer, Prophylactic breast irradiation",

author = "Ben-David, \{Merav A.\} and Corn, \{Benjamin W.\} and Ella Evron and Hadassah Goldberg and Pfeffer, \{Raphael M.\} and Roxoliana Abdah-Bortnyak and Dianna Matceyevsky and Yuliana Weinstein and Orit Golan and Miri Sklair-Levy",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2020",

month = feb,

doi = "10.1016/j.breast.2019.10.011",

language = "אנגלית",

volume = "49",

pages = "70--73",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI

T2 - A secondary analysis

AU - Ben-David, Merav A.

AU - Corn, Benjamin W.

AU - Evron, Ella

AU - Goldberg, Hadassah

AU - Pfeffer, Raphael M.

AU - Abdah-Bortnyak, Roxoliana

AU - Matceyevsky, Dianna

AU - Weinstein, Yuliana

AU - Golan, Orit

AU - Sklair-Levy, Miri

PY - 2020/2

Y1 - 2020/2

N2 - Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

AB - Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

KW - BPE

KW - BRCA

KW - Breast cancer

KW - Prophylactic breast irradiation

UR - https://www.scopus.com/pages/publications/85074880773

U2 - 10.1016/j.breast.2019.10.011

DO - 10.1016/j.breast.2019.10.011

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C2 - 31734591

AN - SCOPUS:85074880773

SN - 0960-9776

VL - 49

SP - 70

EP - 73

JO - Breast

JF - Breast

ER -

Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Abstract

Funding

UN SDGs

Keywords

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