Prolactin receptors in interstitial cells of testes from rats at different stages of development

Robert P.C. Shiu*, G. Paz, C. Faiman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The developmental pattern of prolactin receptors was examined in intact interstitial cells isolated from testes of 19‐day old foetuses (F19), 1 to 45‐day immature (N1 to N45) and adult animals. The prolactin binding activity in F19 interstitial cells is low, being 27% of that found in cells of the adult. There is an abrupt 60% increase in prolactin binding immediately after birth (N1), followed by a slow, but gradual, increase for the next 34 days. A second rapid increase in prolactin binding occurs between days 34 and adulthood which follows an increment in serum prolactin concentrations after day 24. Equilibrium analysis revealed that the receptors in interstitial cells from N1, N34 and adults have similar affinity (Kd= 2.7 to 3.3 times 10‐10M) for prolactin. However, cells from adults contain twice as many prolactin receptors per cell as that of immature animals. This increase in prolactin receptors may play a role in the modulation of interstitial (Leydig) cell function during sexual maturation.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalInternational Journal of Andrology
Volume5
Issue number5
DOIs
StatePublished - Oct 1982
Externally publishedYes

Keywords

  • Leydig cells
  • prolactin receptors
  • sexual development
  • testis

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