Abstract
Objectives: We investigated clinical correlates of atrial fibrillation (AF) progression and evaluated the prognosis of patients demonstrating AF progression in a large population. Background: Progression of paroxysmal AF to more sustained forms is frequently seen. However, not all patients will progress to persistent AF. Methods: We included 1,219 patients with paroxysmal AF who participated in the Euro Heart Survey on AF and had a known rhythm status at follow-up. Patients who experienced AF progression after 1 year of follow-up were identified. Results: Progression of AF occurred in 178 (15%) patients. Multivariate analysis showed that heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension were the only independent predictors of AF progression. Using the regression coefficient as a benchmark, we calculated the HATCH score. Nearly 50% of the patients with a HATCH score >5 progressed to persistent AF compared with only 6% of the patients with a HATCH score of 0. During follow-up, patients with AF progression were more often admitted to the hospital and had more major adverse cardiovascular events. Conclusions: A substantial number of patients progress to sustained AF within 1 year. The clinical outcome of these patients regarding hospital admissions and major adverse cardiovascular events was worse compared with patients demonstrating no AF progression. Factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future.
| Original language | English |
|---|---|
| Pages (from-to) | 725-731 |
| Number of pages | 7 |
| Journal | Journal of the American College of Cardiology |
| Volume | 55 |
| Issue number | 8 |
| DOIs | |
| State | Published - 23 Feb 2010 |
Keywords
- atrial fibrillation
- epidemiology
- prediction
- prognosis
- progression
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In: Journal of the American College of Cardiology, Vol. 55, No. 8, 23.02.2010, p. 725-731.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Progression From Paroxysmal to Persistent Atrial Fibrillation. Clinical Correlates and Prognosis
AU - de Vos, Cees B.
AU - Pisters, Ron
AU - Nieuwlaat, Robby
AU - Prins, Martin H.
AU - Tieleman, Robert G.
AU - Coelen, Robert Jan S.
AU - van den Heijkant, Antonius C.
AU - Allessie, Maurits A.
AU - Crijns, Harry J.G.M.
AU - Andresen, Dieter
AU - Camm, A. John
AU - Davies, Wynn
AU - Capucci, Alessandro
AU - Le´vy, Samuel
AU - Olsson, Bertil
AU - Aliot, Etienne
AU - Breithardt, Gu¨nter
AU - Cobbe, Stuart
AU - Le Heuzey, Jean Yves
AU - Santini, Massimo
AU - Vardas, Panos
AU - Manini, Malika
AU - Bramley, Claire
AU - Laforest, Vale´rie
AU - Taylor, Charles
AU - Del Gaiso, Susan
AU - Huber, Kurt
AU - De Backer, Guy
AU - Sirakova, Vera
AU - Cerbak, Roman
AU - Thayssen, Per
AU - Lehto, Seppo
AU - Blanc, Jean Jacques
AU - Delahaye, Franc¸ois
AU - Kobulia, Bondo
AU - Zeymer, Uwe
AU - Cokkinos, Dennis
AU - Karlocai, Kristof
AU - Graham, Ian
AU - Shelley, Emer
AU - Behar, Shlomo
AU - Maggioni, Aldo
AU - Gonc¸alves, Lino
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AU - Asmussen, Inger
AU - Deckers, Jaap
AU - Stepinska, Janina
AU - Mareev, Vyacheslav
AU - Vasiljevic, Zorana
AU - Riecansky, Igor
AU - Kenda, Miran F.
AU - Alonso, Angeles
AU - Lopez-Sendon, Jose´ Luis
AU - Rosengren, Annika
AU - Buser, Peter
AU - Okay, Tugrul
AU - Sychov, Oleg
AU - Fox, Kevin
AU - Schofield, Peter
AU - Simoons, Maarten
AU - Wood, David
AU - Battler, Alex
AU - Boersma, Eric
AU - Fox, Kim
AU - Komajda, Michel
AU - McGregor, Keith
AU - Mulder, Barbara
AU - Priori, Sylvia
AU - Ryde´n, Lars
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AU - Aroyan, S.
AU - Azarapetyan, L.
AU - Anvari, Anahit
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AU - Pfaffenberger, Stefan
AU - Aydinkoc, Kadriye
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AU - Penka, Martina
AU - Drexel, Heinz
AU - Langer, Peter
AU - Pierard, Luc A.
AU - Legrand, Victor
AU - Blommaert, Dominique
AU - Schroeder, E.
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AU - Ambrozio, Giuseppe
AU - Moruzzi, Paolo
AU - Callegari, Sergio
AU - Saccomanno, Gabriele
AU - Russo, Paolo
AU - Carbonieri, Emanuele
AU - Paino, Anna
AU - Zanetta, Marco
AU - Barducci, Enzo
AU - Cemin, Roberto
AU - Rauhe, Werner
AU - Pitscheider, Walter
AU - Meloni, Marina
AU - Marchi, Sergio Mariano
AU - Di Gennaro, Marco
AU - Calcagno, Sergio
AU - Squaratti, Paola
AU - Quartili, Francesco
AU - Bertocchi, Patrizia
AU - De Martini, Mario
AU - Mantovani, Giuseppe
AU - Komorovsky, Roman
AU - Desideri, Alessandro
AU - Celegon, Leopoldo
AU - Tarantini, Luigi
AU - Catania, Giuseppe
AU - Lucci, Donata
AU - Bianchini, Francesca
AU - Puodziukynas, Aras
AU - Kavoliuniene, Ausra
AU - Barauskiene, Vilija
AU - Aidietis, Audrius
AU - Barysiene, Jurate
AU - Vysniauskas, Vitas
AU - Zukauskiene, Irena
AU - Kazakeviciene, Nijole
AU - Georgievska-Ismail, Ljubica
AU - Poposka, Lidija
AU - Vataman, Eleonora
AU - Grosu, Aurel A.
AU - op Reimer, Wilma Scholte
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AU - Jansen, Chris
AU - Brons, Ritzo
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AU - van Hoogenhuyze, D. C.A.
AU - Veerhoek, M. J.
AU - Kamps, Maria
AU - Haan, D.
AU - van Rijn, Nitolanda
AU - Bootsma, Annette
AU - Baur, Leo
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AU - Fransen, Heidi
AU - Eurlings, Luc
AU - Meeder, Joan
AU - De Boer, M. J.
AU - Winter, Jobst
AU - Broers, Herman
AU - Werter, Chris
AU - Bijl, M.
AU - Versluis, Saskia
AU - Milkowska, Malgorzata
AU - Wozakowska-Kaplon, Beata
AU - Janion, Marianna
AU - Lepska, Lidia
AU - Swiatecka, Grazyna
AU - Kokowicz, Piotr
AU - Cybulski, Jacek
AU - Gorecki, Aleksandr
AU - Szulc, Marcin
AU - Rekosz, Jerzy
AU - Manczak, Rafal
AU - Wnuk-Wojnar, Anna Maria
AU - Trusz-Gluza, M.
AU - Rybicka-Musialik, Anna
AU - Myszor, Jaroslaw
AU - Szpajer, Michal
AU - Cymerman, Krzysztof
AU - Sadowski, Jerzy
AU - Sniezek-Maciejewska, Maria
AU - Ciesla-Dul, Mariola
AU - Gorkiewicz-Kot, Izabela
AU - Grodzicki, Tomasz
AU - Rewiuk, Krzysztof
AU - Kubik, Leszek
AU - Lewit, Jacek
AU - de Sousa, Joao Manuel Frazao Rodrigues
AU - Ferreira, Rafael
AU - Freitas, Antonio
AU - Morais, Joao Carlos Araujo
AU - Pires, Rui
AU - Gomes, M. J.Veloso
AU - Gago, Paula
AU - Candeias, Rui Alexandre C.
AU - Nunes, Luis
AU - Sa, Joao Vitor Miranda
AU - Ventura, Miguel
AU - de Oliveira, Mario
AU - Alves, Luis Brandao
AU - Bostaca, Ioan
AU - Olariu, Codin T.
AU - Dan, G. A.
AU - Dan, Anca
AU - Podoleanu, Cristian
AU - Frigy, Attila
AU - Georgescu, George I.M.
AU - Arsenescu, Catalina
AU - Statescu, Cristian
AU - Sascau, Radu
AU - Dimitrascu, Dan L.
AU - Rancea, Raluca
AU - Shubik, Yuri V.
AU - Duplyakov, Dmitry
AU - Shalak, Marina
AU - Danielyan, Marine
AU - Galyavich, Albert
AU - Zakirova, Venera
AU - Hatala, Robert
AU - Kaliska, Gabriela
AU - Kmec, Jan
AU - Zupan, Igor
AU - Tasie`, Jerneja
AU - Vokac, Damijan
AU - Edvardsson, Nils
AU - Poci, Dritan
AU - Gamra, Habib
AU - Denguir, Hichem
AU - Sepetoglu, Ahmet
AU - Arat-Ozkan, Alev
AU - Orynchak, Mariya
AU - Paliy, Elena
AU - Vakalyuk, I.
AU - Malidze, David
AU - Prog, Rostyslav
AU - Yabluchansky, Myckola Ivanovich
AU - Makienko, Nataliya Volodimirovna
AU - Potpara, Tatjana
AU - Knezevic, Sofija
AU - Randjelovic, Miomir
PY - 2010/2/23
Y1 - 2010/2/23
N2 - Objectives: We investigated clinical correlates of atrial fibrillation (AF) progression and evaluated the prognosis of patients demonstrating AF progression in a large population. Background: Progression of paroxysmal AF to more sustained forms is frequently seen. However, not all patients will progress to persistent AF. Methods: We included 1,219 patients with paroxysmal AF who participated in the Euro Heart Survey on AF and had a known rhythm status at follow-up. Patients who experienced AF progression after 1 year of follow-up were identified. Results: Progression of AF occurred in 178 (15%) patients. Multivariate analysis showed that heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension were the only independent predictors of AF progression. Using the regression coefficient as a benchmark, we calculated the HATCH score. Nearly 50% of the patients with a HATCH score >5 progressed to persistent AF compared with only 6% of the patients with a HATCH score of 0. During follow-up, patients with AF progression were more often admitted to the hospital and had more major adverse cardiovascular events. Conclusions: A substantial number of patients progress to sustained AF within 1 year. The clinical outcome of these patients regarding hospital admissions and major adverse cardiovascular events was worse compared with patients demonstrating no AF progression. Factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future.
AB - Objectives: We investigated clinical correlates of atrial fibrillation (AF) progression and evaluated the prognosis of patients demonstrating AF progression in a large population. Background: Progression of paroxysmal AF to more sustained forms is frequently seen. However, not all patients will progress to persistent AF. Methods: We included 1,219 patients with paroxysmal AF who participated in the Euro Heart Survey on AF and had a known rhythm status at follow-up. Patients who experienced AF progression after 1 year of follow-up were identified. Results: Progression of AF occurred in 178 (15%) patients. Multivariate analysis showed that heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension were the only independent predictors of AF progression. Using the regression coefficient as a benchmark, we calculated the HATCH score. Nearly 50% of the patients with a HATCH score >5 progressed to persistent AF compared with only 6% of the patients with a HATCH score of 0. During follow-up, patients with AF progression were more often admitted to the hospital and had more major adverse cardiovascular events. Conclusions: A substantial number of patients progress to sustained AF within 1 year. The clinical outcome of these patients regarding hospital admissions and major adverse cardiovascular events was worse compared with patients demonstrating no AF progression. Factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future.
KW - atrial fibrillation
KW - epidemiology
KW - prediction
KW - prognosis
KW - progression
UR - http://www.scopus.com/inward/record.url?scp=76449084944&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2009.11.040
DO - 10.1016/j.jacc.2009.11.040
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:76449084944
SN - 0735-1097
VL - 55
SP - 725
EP - 731
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 8
ER -