@article{5578e11da0c64ad0bece9be9f664621a,
title = "Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2",
abstract = "Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.",
keywords = "MacTel, OCT, ellipsoid zone, en face image, macular telangiectasia type 2",
author = "{The MacTel Study Group} and Daniel Pauleikhoff and Roberto Bonelli and Dubis, {Adam M.} and Frederic Gunnemann and Kai Rothaus and {Charbel Issa}, Peter and Heeren, {Tjebo F.C.} and Tunde Peto and Clemons, {Traci E.} and Chew, {Emily Y.} and Bird, {Alan C.} and Sallo, {Ferenc B.} and Sophie Bakri and Bernstein, {Paul S.} and Barbara Blodi and Alexander Brucker and Felicitas Bucher and Mina Chung and Grant Comer and Ian Constable and Michael Cooney and Diana Do and Jacque Duncan and Catherine Egan and Elman, {Michael J.} and Amani Fawzi and Martin Friedlander and Alain Gaudric and Gillies, {Mark C.} and Roger Goldberg and Googe, {Joseph M.} and Robyn Guymer and Patrick Higgins and Frank Holz and Odette Houghton and Hoyng, {Carel B.} and Hubschman, {Jean Pierre} and Chirag Jhaveri and Arshad Khanani and David Lally and Cecilia Lee and Michael Lee and Miller, {Joan W.} and Daniel Miller and Joseph Moisseiev and Robert Murphy and Raja Narayanan and Sandeep Randhawa and Raphaelian, {Paul V.} and Ryan Rich",
note = "Publisher Copyright: {\textcopyright} 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd",
year = "2019",
month = nov,
day = "1",
doi = "10.1111/aos.14110",
language = "אנגלית",
volume = "97",
pages = "e998--e1005",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "John Wiley and Sons Inc.",
number = "7",
}