Progression and new onset of nonalcoholic fatty liver disease in living kidney donors compared to healthy controls

Helena Katchman, Shira Zelber-Sagi, Roni Baruch, Galia Berman, Idit F. Schwartz, Doron Schwartz, Richard Nakache, Yaacov Goykhman, Polina Katz, Oren Shibolet, Moshe Shashar, Ayelet Grupper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: There is growing evidence linking nonalcoholic fatty liver disease (NAFLD) with reduced glomerular filtration rate (GFR). Living kidney donors do not have underlying kidney disease, but have reduced GFR as a result of nephrectomy. Whether kidney donation is associated with a higher risk for development or progression of NAFLD is currently unknown. Methods: Retrospective evaluation of metabolic parameters and sonographic evidence of NAFLD were performed in 232 living kidney donors and 162 healthy controls. Results: A total of 25 donors and 44 controls had NAFLD at baseline. During a mean follow-up of 6.8 years, 6 donors (24%) and 17 controls (38.6%) (P =.29) had a remission of NAFLD, related with decreased body mass index (BMI). The progression of NAFLD fibrosis score was similar in both groups. New onset of NAFLD was observed in 14 (6.8%) donors and 13 (11.01%) controls (P =.211), and was related to increased BMI and a higher baseline Fatty Liver Index score. Neither eGFR nor urine albumin excretion in the donors were related to new onset or progression of NAFLD. Conclusions: Reduced kidney function secondary to kidney donation is not associated with increased incidence or progression of NAFLD.

Original languageEnglish
Article numbere13240
JournalClinical Transplantation
Issue number5
StatePublished - May 2018


  • glomerular filtration rate
  • living kidney donors
  • metabolic syndrome
  • nonalcoholic fatty liver disease


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