Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G. Goren, Ido Yosef, Udi Qimron

Research output: Contribution to journalShort surveypeer-review

Abstract

Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

Original languageEnglish
Pages (from-to)744-746
Number of pages3
JournalTrends in Microbiology
Volume23
Issue number12
DOIs
StatePublished - 2015

Keywords

  • Bacteriophage adsorption
  • Host-range expansion
  • Host-recognition ligand
  • Shaping bacterial microbiome

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