TY - JOUR
T1 - Programming Bacteriophages by Swapping Their Specificity Determinants
AU - Goren, Moran G.
AU - Yosef, Ido
AU - Qimron, Udi
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015
Y1 - 2015
N2 - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.
AB - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.
KW - Bacteriophage adsorption
KW - Host-range expansion
KW - Host-recognition ligand
KW - Shaping bacterial microbiome
UR - http://www.scopus.com/inward/record.url?scp=84951335911&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2015.10.006
DO - 10.1016/j.tim.2015.10.006
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AN - SCOPUS:84951335911
SN - 0966-842X
VL - 23
SP - 744
EP - 746
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -
