Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P. Talmi; Robert P. Takes; Eran E. Alon; Iain J. Nixon; Fernando López; Remco de Bree; Juan P. Rodrigo; Ashok R. Shaha; Gyorgy B. Halmos; Alessandra Rinaldo; Alfio Ferlito

doi:10.1002/hed.25080

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Yoav P. Talmi, Robert P. Takes^*, Eran E. Alon, Iain J. Nixon, Fernando López, Remco de Bree, Juan P. Rodrigo, Ashok R. Shaha, Gyorgy B. Halmos, Alessandra Rinaldo, Alfio Ferlito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed. Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09. Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

Original language	English
Pages (from-to)	1082-1090
Number of pages	9
Journal	Head and Neck
Volume	40
Issue number	5
DOIs	https://doi.org/10.1002/hed.25080
State	Published - May 2018

Keywords

head and neck squamous cell carcinoma
lymph node metastasis
lymph node ratio
neck dissection
prognosis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.25080

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@article{0efaf55d3f8f45d8bde3237517d8b565,

title = "Prognostic value of lymph node ratio in head and neck squamous cell carcinoma",

abstract = "Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed. Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09. Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.",

keywords = "head and neck squamous cell carcinoma, lymph node metastasis, lymph node ratio, neck dissection, prognosis",

author = "Talmi, {Yoav P.} and Takes, {Robert P.} and Alon, {Eran E.} and Nixon, {Iain J.} and Fernando L{\'o}pez and {de Bree}, Remco and Rodrigo, {Juan P.} and Shaha, {Ashok R.} and Halmos, {Gyorgy B.} and Alessandra Rinaldo and Alfio Ferlito",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = may,

doi = "10.1002/hed.25080",

language = "אנגלית",

volume = "40",

pages = "1082--1090",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

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TY - JOUR

T1 - Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

AU - Talmi, Yoav P.

AU - Takes, Robert P.

AU - Alon, Eran E.

AU - Nixon, Iain J.

AU - López, Fernando

AU - de Bree, Remco

AU - Rodrigo, Juan P.

AU - Shaha, Ashok R.

AU - Halmos, Gyorgy B.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018/5

Y1 - 2018/5

N2 - Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed. Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09. Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

AB - Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC). Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed. Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09. Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation.

KW - head and neck squamous cell carcinoma

KW - lymph node metastasis

KW - lymph node ratio

KW - neck dissection

KW - prognosis

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SN - 1043-3074

VL - 40

SP - 1082

EP - 1090

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -

Prognostic value of lymph node ratio in head and neck squamous cell carcinoma

Abstract

Keywords

UN SDGs

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