TY - JOUR
T1 - Prognostic value of histologic subtypes in renal cell carcinoma
T2 - A multicenter experience
AU - Patard, Jean Jacques
AU - Leray, Emmanuelle
AU - Rioux-Leclercq, Nathalie
AU - Cindolo, Luca
AU - Ficarra, Vincenzo
AU - Zisman, Amnon
AU - De La Taille, Alexandre
AU - Tostain, Jacques
AU - Artibani, Walter
AU - Abbou, Claude C.
AU - Lobel, Bernard
AU - Guillé, François
AU - Chopin, Dominique K.
AU - Mulders, Peter F.A.
AU - Wood, Christopher G.
AU - Swanson, David A.
AU - Figlin, Robert A.
AU - Belldegrun, Arie S.
AU - Pantuck, Allan J.
PY - 2005/4/20
Y1 - 2005/4/20
N2 - Purpose: To analyze to what extent histologic subtype is of prognostic importance in renal cell carcinoma based on a large, international, multicenter experience. Patients and Methods: Four thousand sixty-three patients from eight international centers were included in this retrospective study. Histologic subtype (1997 International Union Against Cancer [UICC] criteria of tumor response), age, sex, TNM stage, Fuhrman grade, tumor size, Eastern Cooperative Oncology Goup performance status (ECOG PS), and overall survival were determined in all cases. The prognostic values of clear cell, papillary, and chromophobe histologic features were assessed by uni- and multivariate analysis using the Kaplan-Meier method and Cox model, respectively. Results: Clear cell, papillary, and chromophobe carcinomas accounted for 3,564 (87.7%), 396 (9.7%) and 103 (2.5%) cases, respectively. In univariate analysis, a trend toward a better survival was observed when clear cell, papillary, and chromophobe histologies were considered prognostic categories (log-rank P = .0007). However, in multivariate analysis, TNM stage, Fuhrman grade and ECOG PS, but not histology, were retained as independent prognostic variables (P < .001). Conclusion: The stratification in three main renal cell carcinoma histologic subtypes as defined by the 1997 UICC-American Joint Committee on Cancer consensus should not be considered a major prognostic variable comparable to TNM stage, Fuhrman grade and ECOG PS.
AB - Purpose: To analyze to what extent histologic subtype is of prognostic importance in renal cell carcinoma based on a large, international, multicenter experience. Patients and Methods: Four thousand sixty-three patients from eight international centers were included in this retrospective study. Histologic subtype (1997 International Union Against Cancer [UICC] criteria of tumor response), age, sex, TNM stage, Fuhrman grade, tumor size, Eastern Cooperative Oncology Goup performance status (ECOG PS), and overall survival were determined in all cases. The prognostic values of clear cell, papillary, and chromophobe histologic features were assessed by uni- and multivariate analysis using the Kaplan-Meier method and Cox model, respectively. Results: Clear cell, papillary, and chromophobe carcinomas accounted for 3,564 (87.7%), 396 (9.7%) and 103 (2.5%) cases, respectively. In univariate analysis, a trend toward a better survival was observed when clear cell, papillary, and chromophobe histologies were considered prognostic categories (log-rank P = .0007). However, in multivariate analysis, TNM stage, Fuhrman grade and ECOG PS, but not histology, were retained as independent prognostic variables (P < .001). Conclusion: The stratification in three main renal cell carcinoma histologic subtypes as defined by the 1997 UICC-American Joint Committee on Cancer consensus should not be considered a major prognostic variable comparable to TNM stage, Fuhrman grade and ECOG PS.
UR - http://www.scopus.com/inward/record.url?scp=21044433148&partnerID=8YFLogxK
U2 - 10.1200/JCO.2005.07.055
DO - 10.1200/JCO.2005.07.055
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C2 - 15837991
AN - SCOPUS:21044433148
SN - 0732-183X
VL - 23
SP - 2763
EP - 2771
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 12
ER -
