Prognostic significance of changes in serum transcobalamin levels in cancer patients with chemotherapy-induced granulocytopenia

A. Sulkes, B. Rachmilewitz, M. Rachmilewitz, Z. Fuks

Research output: Contribution to journalArticlepeer-review

Abstract

Serum transcobalamin (TC) levels were determined daily in 14 adults suffering from advanced nonhematological malignancies and hospitalized because of chemotherapy-induced leukopenia and fever. Even during the nadir leukocyte count, TCI and TCII serum levels were normal or only slightly decreased indicating that bone marrow activity was not competely suppressed. A significant increase in serum TCII level was observed in all patients, with peak values occurring an average of 4.5 days from admission at a time when the median leukocyte count was 2,300/mm3. Full white cell count recovery followed this peak TCII elevation within a mean of 5.5 days in all patients, coinciding with a fall in TCII levels to basal values. The rise in serum TCII level appears to be an early indicator for imminent bone marrow recovery in myelosuppressed patients.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalOncology
Volume40
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

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