TY - JOUR
T1 - Prognostic Factors in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck
AU - Bachar, Gideon
AU - Mizrachi, Aviram
AU - Rabinovics, Naomi
AU - Guttman, Dan
AU - Shpitzer, Thomas
AU - Ad-El, Dean
AU - Hadar, Tuvia
N1 - Publisher Copyright:
© 2016 SAGE Publications.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated carcinoma was an independent predictor of poorer disease-free survival, and olderage was found to be an independent predictor of poorer overall survival. We found no significant difference in disease-free or disease-specific survival among patients with parotid involvement, neck involvement, or both. In our series, the site of nodal involvement appeared to have no prognostic significance in patients with metastatic cutaneous SCC of the head and neck.
AB - Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated carcinoma was an independent predictor of poorer disease-free survival, and olderage was found to be an independent predictor of poorer overall survival. We found no significant difference in disease-free or disease-specific survival among patients with parotid involvement, neck involvement, or both. In our series, the site of nodal involvement appeared to have no prognostic significance in patients with metastatic cutaneous SCC of the head and neck.
UR - http://www.scopus.com/inward/record.url?scp=85082480470&partnerID=8YFLogxK
U2 - 10.1177/0145561316095010-1106
DO - 10.1177/0145561316095010-1106
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AN - SCOPUS:85082480470
SN - 0145-5613
VL - 95
SP - 1
EP - 10
JO - Ear, Nose and Throat Journal
JF - Ear, Nose and Throat Journal
IS - 10-11
ER -
