Prognostic factors in differentiated thyroid cancer revisited

Eran Glikson*, Eran Alon, Lev Bedrin, Yoav P. Talmi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: More than 90% of all thyroid cancers are differentiated thyroid carcinomas (DTC) with a 10 year survival rate greater than 90%. The commonly used risk stratification systems for DTC include: European Organization for Research and Treatment of Cancer (EORTC), AGES (Age, histologic Grade, Extent of tumor, Size), AMES (Metastasis) and MACIS (Completeness of resection, local Invasion). Other systems are also utilized. Several new factors that may be involved in DTC risk stratification have emerged in recent studies, with other “traditional” factors being challenged. Objectives: To present recent updates in the literature on new potential prognostic factors for DTC. Methods: We conducted a literature review and analysis of publications regarding DTC prognostic factors or risk stratification published in the last 10 years. Results: Several new factors with potential prognostic implications for DTC were noted, including family history, lymph node involvement parameters, positive PET-CT findings, multifocal disease, thyroglobulin level and several molecular markers including BRAF. Increasing age is associated with poorer outcome in DTC; however, recent studies suggest that the cutoff point of 45 years may be contested. Furthermore, several studies have shown contradictory results regarding male gender as a negative prognostic factor, thus questioning its prognostic significance. Conclusions: A number of new factors with potential prognostic implications for DTC have emerged and should be addressed. However, their role and possible inclusion in new staging systems has yet to be determined.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalIsrael Medical Association Journal
Volume19
Issue number2
StatePublished - Feb 2017

Keywords

  • Differentiated thyroid cancer (DTC)
  • Prognostic factors
  • Risk stratification
  • Staging systems

Fingerprint

Dive into the research topics of 'Prognostic factors in differentiated thyroid cancer revisited'. Together they form a unique fingerprint.

Cite this