TY - JOUR
T1 - Prognostic factors for adult single cord blood transplantation among European and Japanese populations
T2 - the Eurocord/ALWP-EBMT and JSHCT/JDCHCT collaborative study
AU - Kanda, Junya
AU - Hayashi, Hiromi
AU - Ruggeri, Annalisa
AU - Kimura, Fumihiko
AU - Volt, Fernanda
AU - Takahashi, Satoshi
AU - Labopin, Myriam
AU - Kako, Shinichi
AU - Tozatto-Maio, Karina
AU - Yano, Shingo
AU - Sanz, Guillermo
AU - Uchida, Naoyuki
AU - Van Lint, Maria Teresa
AU - Kato, Seiko
AU - Mohty, Mohamad
AU - Forcade, Edouard
AU - Kanamori, Heiwa
AU - Sierra, Jorge
AU - Ohno, Yuju
AU - Saccardi, Riccardo
AU - Fukuda, Takahiro
AU - Ichinohe, Tatsuo
AU - Takanashi, Minoko
AU - Rocha, Vanderson
AU - Okamoto, Shinichiro
AU - Nagler, Arnon
AU - Atsuta, Yoshiko
AU - Gluckman, Eliane
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Large differences in patient and transplant backgrounds make it difficult to identify consistent prognostic factors of unrelated cord blood transplantation (UCBT) among different populations. Thus, we performed a collaborative study between Eurocord/ALWP-EBMT and JSHCT/JDCHCT. Adults with acute leukaemia who underwent a single UCBT were eligible. In total, 3764 and 1027 patients of the JSHCT/JDCHCT and Eurocord/ALWP-EBMT registries, respectively, were included. The median ages of the Japanese and European cohorts were 51 and 38 years, respectively. Three or more HLA mismatches were more frequently observed in the Japanese cohort. The median total nucleated cell (TNC) counts were 2.58 and 3.51 × 107/kg in the Japanese and European cohorts, respectively. Anti-thymocyte globulin was used in only 2% of the Japanese cohort compared with 65% of the European cohort. The 3-year overall survival (OS) was 41% in JSHCT/JDCHCT and 33% in Eurocord/ALWP-EBMT. In the multivariate analysis, TNC dose and HLA matching had no significant effect on OS in either cohort, whereas year of transplantation, age, and refined disease risk index affected OS in both cohorts. Despite considerable differences in characteristics between the Japanese and European cohorts, we observed similar prognostic factors affecting UCBT outcomes in adult patients with acute leukaemia in both registries.
AB - Large differences in patient and transplant backgrounds make it difficult to identify consistent prognostic factors of unrelated cord blood transplantation (UCBT) among different populations. Thus, we performed a collaborative study between Eurocord/ALWP-EBMT and JSHCT/JDCHCT. Adults with acute leukaemia who underwent a single UCBT were eligible. In total, 3764 and 1027 patients of the JSHCT/JDCHCT and Eurocord/ALWP-EBMT registries, respectively, were included. The median ages of the Japanese and European cohorts were 51 and 38 years, respectively. Three or more HLA mismatches were more frequently observed in the Japanese cohort. The median total nucleated cell (TNC) counts were 2.58 and 3.51 × 107/kg in the Japanese and European cohorts, respectively. Anti-thymocyte globulin was used in only 2% of the Japanese cohort compared with 65% of the European cohort. The 3-year overall survival (OS) was 41% in JSHCT/JDCHCT and 33% in Eurocord/ALWP-EBMT. In the multivariate analysis, TNC dose and HLA matching had no significant effect on OS in either cohort, whereas year of transplantation, age, and refined disease risk index affected OS in both cohorts. Despite considerable differences in characteristics between the Japanese and European cohorts, we observed similar prognostic factors affecting UCBT outcomes in adult patients with acute leukaemia in both registries.
UR - http://www.scopus.com/inward/record.url?scp=85070791227&partnerID=8YFLogxK
U2 - 10.1038/s41375-019-0534-5
DO - 10.1038/s41375-019-0534-5
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C2 - 31409921
AN - SCOPUS:85070791227
SN - 0887-6924
VL - 34
SP - 128
EP - 137
JO - Leukemia
JF - Leukemia
IS - 1
ER -
