TY - JOUR
T1 - Prognosis and Outcome of Cerebral Sinus Venous Thrombosis - A Multicenter Cohort Study
AU - Simaan, Naaem
AU - Honig, Asaf
AU - Hallevi, Hen
AU - Seyman, Estelle
AU - Rotschild, Ofer
AU - Assayag, Einor Ben
AU - Filioglo, Andrei
AU - Peretz, Shlomi
AU - Mendel, Rom
AU - Barnea, Rani
AU - Auriel, Eitan
AU - Aladdin, Shorooq
AU - Orion, David
AU - Darawsha, Khalil
AU - Shbat, Fadi
AU - Leker, Ronen R.
AU - Molad, Jeremy
N1 - Publisher Copyright:
© 2023 Naaem Simaan et al.
PY - 2023
Y1 - 2023
N2 - Objectives. Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype and data regarding prognostic factors to predict outcomes are lacking. Thus, we aimed to identify predictors for outcome among CSVT patients. Materials and Methods. Prospective CSVT databases from four academic medical centers were retrospectively studied. Demographics, clinical presentations, risk factors, radiological, and outcome parameters were compared. Results. Out of 508 patients diagnosed with CSVT, 21 patients (4%) died, and 91 (18.6%) had unfavorable outcome (mRS≥2). Age (55.0 vs. 38.5, p<0.001), hypertension (26% vs. 6%, p<0.001), hyperlipidemia (23% vs. 6%, p<0.001), diabetes (17% vs. 4%, p<0.001), malignancy (35% vs. 11%, p<0.001), absence of headache (51% vs. 78%, p<0.001), focal neurological deficit (54% vs. 19%, p<0.001), and ICH (28% vs. 13%, p<0.001) were all associated with unfavorable outcome. After multivariate analysis malignancy (OR 4.2, p=0.003), the presence of focal neurological deficit (OR 5.2, p<0.001) and the presence of headache upon presentation (OR 0.334, p=0.018) remained significant predictors for favorable outcome. Conclusions. Among CSVT patients, malignancy, focal neurological deficits, and absence of headache at presentation were associated with unfavorable outcomes.
AB - Objectives. Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype and data regarding prognostic factors to predict outcomes are lacking. Thus, we aimed to identify predictors for outcome among CSVT patients. Materials and Methods. Prospective CSVT databases from four academic medical centers were retrospectively studied. Demographics, clinical presentations, risk factors, radiological, and outcome parameters were compared. Results. Out of 508 patients diagnosed with CSVT, 21 patients (4%) died, and 91 (18.6%) had unfavorable outcome (mRS≥2). Age (55.0 vs. 38.5, p<0.001), hypertension (26% vs. 6%, p<0.001), hyperlipidemia (23% vs. 6%, p<0.001), diabetes (17% vs. 4%, p<0.001), malignancy (35% vs. 11%, p<0.001), absence of headache (51% vs. 78%, p<0.001), focal neurological deficit (54% vs. 19%, p<0.001), and ICH (28% vs. 13%, p<0.001) were all associated with unfavorable outcome. After multivariate analysis malignancy (OR 4.2, p=0.003), the presence of focal neurological deficit (OR 5.2, p<0.001) and the presence of headache upon presentation (OR 0.334, p=0.018) remained significant predictors for favorable outcome. Conclusions. Among CSVT patients, malignancy, focal neurological deficits, and absence of headache at presentation were associated with unfavorable outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85176148143&partnerID=8YFLogxK
U2 - 10.1155/2023/8016006
DO - 10.1155/2023/8016006
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AN - SCOPUS:85176148143
SN - 0001-6314
VL - 2023
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
M1 - 8016006
ER -
