Progestogens in non gynecological indications

Howard J.A. Carp*, Matityahu Zolti, Christa Nadjafi-Triebsch

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A whole "orchestra" of hormones and enzymes are required in order to achieve an optimal hormonal supply for bodily functions. Progesterone appears to be the key-factor for health not only in women, but also in men and children, in patients with depression, sleep disorders, multiple sclerosis, spinal cord-neurodegeneration, brain trauma, CVA, epileptic seizures, prostate hyperplasia, erectile dysfunction and more. Progesterone has anti-inflammatory and anti-oxidative effects, is a mild diuretic, a natural anti-convulsive, supports thyroid function, helps to normalize the blood-sugar level, normalizes zinc-and copper-levels. Since Progesterone activates the tumor-suppressor gene p53, suppresses the tumor-supporting gene Bcl-2, promotes apoptosis and prevents metastasis by inhibiting matrix metalloproteinases, its supplementation in cases of progesterone deficiency is of importance for cancer-prophylaxis. Furthermore, progesterone is responsible for a number of physiological processes: Interaction with the GABA-receptor-complex in the brain, leading to sedative and anxiolytic effects and better quality of sleep, interactions with fatty tissue and the kidneys. Progesterone increases pulmonary gas-exchange, reduces alveolar CO2-pressure and displays immune-suppressive effects, affects sexual behavior and has anti-inflammatory and anti-oxidative effects.

Original languageEnglish
Title of host publicationProgestogens in Obstetrics and Gynecology
PublisherSpringer International Publishing
Number of pages17
ISBN (Electronic)9783030525088
ISBN (Print)9783030525071
StatePublished - 4 Jan 2021


Dive into the research topics of 'Progestogens in non gynecological indications'. Together they form a unique fingerprint.

Cite this