Profiling gene expression in kidney development.

Benjamin Dekel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Insights into the normal development of the kidney have been derived from metanephric organ cultures, knockout mice and the later definition of the responsible single genetic abnormalities in some human congenital renal tract malformations. Deciphering of the human genome and the ability to examine multiple messenger RNA has opened new vistas and the capacity to begin to understand the complex kidney developmental process. In this review we focus on recent large-scale gene expression profiles performed during normal murine and human nephrogenesis and suggest how they might provide insights into normal kidney development as well as aberrations of this normal process that may result in renal dysplasia or pediatric renal malignancy (Wilms' tumor).

Original languageEnglish
Pages (from-to)e1-6
Issue number1
StatePublished - 2003
Externally publishedYes


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