Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern

Oshrat Raz; Galit Granot; Metsada Pasmanik-Chor; Pia Raanani; Uri Rozovski

doi:10.1016/j.exphem.2020.04.001

Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern

Oshrat Raz, Galit Granot^*, Metsada Pasmanik-Chor, Pia Raanani, Uri Rozovski

^*Corresponding author for this work

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Abstract

Approximately 10% of the human transcriptome is composed of circular RNAs (circRNAs). These are non-coding RNA molecules in which a covalent bond between the 3′ and 5′ forms a stable circular loop. Herein, we profiled the expression of 13,368 cricRNAS in 21 patients with chronic lymphocytic leukemia (CLL). Regardless of clinical, genetic, or prognostic characteristics, CLL cells share a unique expression profile distinguishable from that of normal B cells. Specifically, 859 circRNAs from 592 genes were differentially expressed (fold change ≥2 and false discovery rate ≤0.05). Whether dysregulation of circRNAs contributes to the pathogenesis of CLL remains to be determined.

Original language	English
Pages (from-to)	8-12
Number of pages	5
Journal	Experimental Hematology
Volume	85
DOIs	https://doi.org/10.1016/j.exphem.2020.04.001
State	Published - May 2020

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10.1016/j.exphem.2020.04.001

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abstract = "Approximately 10% of the human transcriptome is composed of circular RNAs (circRNAs). These are non-coding RNA molecules in which a covalent bond between the 3′ and 5′ forms a stable circular loop. Herein, we profiled the expression of 13,368 cricRNAS in 21 patients with chronic lymphocytic leukemia (CLL). Regardless of clinical, genetic, or prognostic characteristics, CLL cells share a unique expression profile distinguishable from that of normal B cells. Specifically, 859 circRNAs from 592 genes were differentially expressed (fold change ≥2 and false discovery rate ≤0.05). Whether dysregulation of circRNAs contributes to the pathogenesis of CLL remains to be determined.",

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AU - Rozovski, Uri

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Profiling and bioinformatics analyses reveal chronic lymphocytic leukemia cells share a unique circular RNA expression pattern

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