Productive replication of caprine arthritis-encephalitis virus is associated with induction of apoptosis

Raya Gendelman, Yael Orzech, Pnina Mashiah, Mira Birenbaum, Arnona Gazit, Abraham Yaniv

Research output: Contribution to journalArticlepeer-review

Abstract

Caprine arthritis-encephalitis virus (CAEV), an ungulate lentivirus, causes a natural infection in goats. The present report demonstrates that in vitro, CAEV infection is associated with apoptosis, characterized by morphological changes such as condensation of chromatin and the appearance of apoptotic bodies. The presence of DNA fragments was documented by the appearance of a DNA 'ladder' in agarose gel electrophoresis, as well as by in situ end-labelling of DNA ends. In addition, flow cytometric analyses revealed the presence of a hypodiploid peak that gradually appeared as virus infection progressed.

Original languageEnglish
Pages (from-to)801-805
Number of pages5
JournalJournal of General Virology
Volume78
Issue number4
DOIs
StatePublished - Apr 1997

Fingerprint

Dive into the research topics of 'Productive replication of caprine arthritis-encephalitis virus is associated with induction of apoptosis'. Together they form a unique fingerprint.

Cite this