Production of interleukin-1 by mononuclear cells of newborns and their mothers

H. Bessler, L. Sirota, F. Dulitzky, M. Djaldetti

Research output: Contribution to journalArticlepeer-review


The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity for IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalClinical and Experimental Immunology
Issue number3
StatePublished - 1987
Externally publishedYes


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