Abstract
The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity for IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.
Original language | English |
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Pages (from-to) | 655-661 |
Number of pages | 7 |
Journal | Clinical and Experimental Immunology |
Volume | 68 |
Issue number | 3 |
State | Published - 1987 |
Externally published | Yes |