Prodrug activation gated by a molecular "OR" logic trigger

Roey J. Amir, Mikhail Popkov, Richard A. Lerner, Carlos F. Barbas, Doron Shabat

Research output: Contribution to journalArticlepeer-review

Abstract

(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).

Original languageEnglish
Pages (from-to)4378-4381
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number28
DOIs
StatePublished - 11 Jul 2005

Keywords

  • Catalytic antibodies
  • Drug delivery
  • Enzymes
  • Logic gates
  • Prodrugs

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