Prodrug activation gated by a molecular "OR" logic trigger

Roey J. Amir; Mikhail Popkov; Richard A. Lerner; Carlos F. Barbas; Doron Shabat

doi:10.1002/anie.200500842

Prodrug activation gated by a molecular "OR" logic trigger

Roey J. Amir, Mikhail Popkov, Richard A. Lerner, Carlos F. Barbas, Doron Shabat

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).

Original language	English
Pages (from-to)	4378-4381
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	28
DOIs	https://doi.org/10.1002/anie.200500842
State	Published - 11 Jul 2005

Keywords

Catalytic antibodies
Drug delivery
Enzymes
Logic gates
Prodrugs

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10.1002/anie.200500842

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Prodrug activation gated by a molecular "OR" logic trigger

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