Procarbazine, CCNU and vincristine (PCV) combination chemotherapy for brain tumors

G. Brufman, J. Halpern, A. Sulkes, R. Catane, S. Biran

Research output: Contribution to journalArticlepeer-review


12 patients with brain tumors were treated with a combination of procarbazine, CCNU (bis-2- chloroethyl-3-cyclohexyl-1-nitrosourea) and vincristine. 3 of 8 patients (37.5%) with primary brain tumors responded to chemotherapy, with a mean duration of 9.3 months. The mean survival of responders was 11.7 months, versus 3.6 months for nonresponders. 4 patients with metastatic brain tumors were also treated with the same combination chemotherapy only 1, suffering from a lymphoma of the brain, responded partially.

Original languageEnglish
Pages (from-to)239-241
Number of pages3
Issue number4
StatePublished - 1984
Externally publishedYes


  • Brain tumors
  • CCNU
  • Chemotherapy
  • Procarbazine
  • Vincristine


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