PRISM: A web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

Alper Baspinar; Engin Cukuroglu; Ruth Nussinov; Ozlem Keskin; Attila Gursoy

doi:10.1093/nar/gku397

PRISM: A web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

Alper Baspinar, Engin Cukuroglu, Ruth Nussinov, Ozlem Keskin, Attila Gursoy^*

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.

Original language	English
Pages (from-to)	W285-W289
Journal	Nucleic Acids Research
Volume	42
Issue number	W1
DOIs	https://doi.org/10.1093/nar/gku397
State	Published - 1 Jul 2014

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10.1093/nar/gku397

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abstract = "The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.",

author = "Alper Baspinar and Engin Cukuroglu and Ruth Nussinov and Ozlem Keskin and Attila Gursoy",

note = "Funding Information: National Cancer Institute, National Institutes of Health (NIH) [HHSN261200800001E] (whole or in part); Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research (in part); Scientific and Technological Research Council of Turkey (TUBITAK) [113E164]. Conflict of interest statement. None declared.",

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doi = "10.1093/nar/gku397",

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AU - Cukuroglu, Engin

AU - Nussinov, Ruth

AU - Keskin, Ozlem

AU - Gursoy, Attila

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PRISM: A web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

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