PRISM: A web server and repository for prediction of protein-protein interactions and modeling their 3D complexes

Alper Baspinar, Engin Cukuroglu, Ruth Nussinov, Ozlem Keskin, Attila Gursoy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.

Original languageEnglish
Pages (from-to)W285-W289
JournalNucleic Acids Research
Volume42
Issue numberW1
DOIs
StatePublished - 1 Jul 2014

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