Abstract
Protein molecules and their building blocks self-assemble to create various shapes. To design nanostructures, the goal is to manipulate predictably the self-assembly into a target shape. Here, we focus on a shape-based design principles and strategies from a protein folding perspective. We largely center on nanotubes, which may constitute the simplest macromolecular 3D shape, and provide carbon nanotube analogies. We touch on the mechanism of formation of lipid tubules with the expectation that the mechanisms of protein and lipid tube formation share general conceptual similarity. Last, we illustrate how incorporation of synthetic, nonproteinogenic residues can assist in the shape-based design by restricting the conformational space sampled by the peptides while at the same time rendering them resistant to proteolysis.
Original language | English |
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Title of host publication | Peptide Materials |
Subtitle of host publication | From Nanostructures to Applications |
Publisher | John Wiley and Sons |
Pages | 171-189 |
Number of pages | 19 |
ISBN (Print) | 9781119953739 |
DOIs | |
State | Published - 27 Mar 2013 |
Keywords
- Building blocks
- Modeling
- Nanobiology
- Nanotube design
- Protein folding
- Self-assembly