Principles of protein-protein interactions: What are the preferred ways for proteins to interact?

The main reason for the increased interest in protein-protein interactions are the better quantization of the key features controlling the interactions which will lead to higher success in the prediction of protein associations. Such an analysis will focus on protein surfaces. Meanwhile, it is important to have the structures of the proteins to identify the residues and atom groups that line the protein surface. The determination of which residues and atoms are on the surface is usually carried out through calculations of the surface area that is accessible to the solvent.