Principles of protein-protein interactions: What are the preferred ways for proteins to interact?

Ozlem Keskin, Attila Gursoy, Buyong Ma, Ruth Nussinov

Research output: Contribution to journalReview articlepeer-review

Abstract

The main reason for the increased interest in protein-protein interactions are the better quantization of the key features controlling the interactions which will lead to higher success in the prediction of protein associations. Such an analysis will focus on protein surfaces. Meanwhile, it is important to have the structures of the proteins to identify the residues and atom groups that line the protein surface. The determination of which residues and atoms are on the surface is usually carried out through calculations of the surface area that is accessible to the solvent.

Original languageEnglish
Pages (from-to)1225-1244
Number of pages20
JournalChemical Reviews
Volume108
Issue number4
DOIs
StatePublished - Apr 2008

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