TY - JOUR
T1 - Priming in vitro maturation cycles with gonadotropins
T2 - Salvage treatment for nonresponding patients
AU - Shalom-Paz, Einat
AU - Almog, Benny
AU - Wiser, Amir
AU - Levin, Ishai
AU - Reinblatt, Shauna
AU - Das, Mousmi
AU - Son, Weon Young
AU - Hananel, Holzer
PY - 2011/8
Y1 - 2011/8
N2 - Objective: To compare the treatment outcomes in in vitro maturation (IVM) cycles primed with human menopausal gonadotropin with those for pure IVM cycles in patients with polycystic ovary syndrome. Design: Prospective observational. Setting: University-based tertiary medical center. Patient(s): Patients undergoing IVM cycles (primed IVM, 47; pure IVM, 118). Intervention(s): IVM treatment with and without human menopausal gonadotropin stimulation. Main Outcome Measure(s): Pregnancy rates. Result(s): The clinical pregnancy rate demonstrated a tendency toward improvement in the primed IVM group (53.1% versus 43.2%, respectively) with better implantation and delivery rates (20.1% versus 14.4%; 95% confidence intervals 1.0-3.06 and 40.4% versus 24.6%; 95% confidence intervals 0.1-0.8, respectively). We found no significant difference in pure IVM compared with primed IVM in the number of eggs collected, size of leading follicle, fertility rate, cleavage rate, and the number of embryos transferred. Total mature eggs and maturation rate were significantly higher in the group of pure IVM (11 ± 2.1 versus 8.7 ± 0.5 and 68.5% ± 17.5% versus 60.9% ± 0.4%, respectively). Importantly, the endometrial thickness was significantly improved in primed IVM cycles (7.9 ± 1.9 mm versus 7.1 ± 0.8 mm), possibly leading to better implantation and pregnancy rates. Conclusion(s): Patients who fail to demonstrate endometrial or follicular growth during IVM cycles may benefit from gonadotropin priming during the same cycle.
AB - Objective: To compare the treatment outcomes in in vitro maturation (IVM) cycles primed with human menopausal gonadotropin with those for pure IVM cycles in patients with polycystic ovary syndrome. Design: Prospective observational. Setting: University-based tertiary medical center. Patient(s): Patients undergoing IVM cycles (primed IVM, 47; pure IVM, 118). Intervention(s): IVM treatment with and without human menopausal gonadotropin stimulation. Main Outcome Measure(s): Pregnancy rates. Result(s): The clinical pregnancy rate demonstrated a tendency toward improvement in the primed IVM group (53.1% versus 43.2%, respectively) with better implantation and delivery rates (20.1% versus 14.4%; 95% confidence intervals 1.0-3.06 and 40.4% versus 24.6%; 95% confidence intervals 0.1-0.8, respectively). We found no significant difference in pure IVM compared with primed IVM in the number of eggs collected, size of leading follicle, fertility rate, cleavage rate, and the number of embryos transferred. Total mature eggs and maturation rate were significantly higher in the group of pure IVM (11 ± 2.1 versus 8.7 ± 0.5 and 68.5% ± 17.5% versus 60.9% ± 0.4%, respectively). Importantly, the endometrial thickness was significantly improved in primed IVM cycles (7.9 ± 1.9 mm versus 7.1 ± 0.8 mm), possibly leading to better implantation and pregnancy rates. Conclusion(s): Patients who fail to demonstrate endometrial or follicular growth during IVM cycles may benefit from gonadotropin priming during the same cycle.
KW - In vitro maturation
KW - PCOS
KW - minimal stimulation
KW - pregnancy rate
UR - http://www.scopus.com/inward/record.url?scp=79960624808&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2011.06.003
DO - 10.1016/j.fertnstert.2011.06.003
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C2 - 21718997
AN - SCOPUS:79960624808
SN - 0015-0282
VL - 96
SP - 340
EP - 343
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -