Primary vitreoretinal lymphoma masquerading as refractory retinitis

Ofira Zloto, Amir E. Abd Elkader, Ido Didi Fabian, Vicktoria Vishnevskia-Dai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis. Methods: Retrospective review of the patient's clinical, histopathological and imaging records. Results: Cytopathology was negative for malignancy, and preliminary polymerase chain reaction results supported the diagnosis of varicella zoster virus retinitis. Therefore, the patient was treated with antiviral therapy. However, under this treatment, the retinitis progressed. As a result, primary vitreoretinal lymphoma was suspected, and empirical treatment with intravitreal methotrexate injections was started. Under this treatment, the ocular features improved. Five months after initial ocular presentation and ocular resolution, the patient presented with central nervous system lymphoma. Conclusion: This case should raise the awareness of the variable clinical presentations, the challenging diagnosis and treatment of primary vitreoretinal lymphoma. All cases should be continuously systemically evaluated.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalCase Reports in Ophthalmology
Issue number3
StatePublished - 2015
Externally publishedYes


  • Diagnostic vitrectomy
  • Intravitreal methotrexate
  • Posterior uveitis
  • Primary central nervous system lymphoma
  • Primary vitreoretinal lymphoma


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