Primary systemic therapy and whole breast irradiation for locally advanced breast cancer: A systematic review

Orit Kaidar-Person, Abraham Kuten, Yazid Belkacemi

Research output: Contribution to journalReview articlepeer-review

Abstract

The current management of locally advanced breast cancer (LABC) is based on tri-modality treatment including chemotherapy, radiotherapy and surgery. The concept of preoperative concurrent or sequential chemoradiation for LABC was initially reported more than a decade ago; however this concept did not gain popularity because of the low benefit/risk ratio and the lack of strong data supporting the concept. The purpose of the current systematic review was to explore the published data about preoperative chemoradiation (sequential and/or concurrent) using whole breast irradiation in terms of toxicity and outcome.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalCritical Reviews in Oncology/Hematology
Volume92
Issue number2
DOIs
StatePublished - 1 Nov 2014
Externally publishedYes

Keywords

  • Breast cancer
  • Chemoradiation
  • Chemotherapy
  • Irradiation
  • Neoadjuvant
  • Preoperative
  • Radiotherapy

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