Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

Martin Biel; Wolfram Altenhofen; Roger Hullin; Jost Ludwig; Marc Freichel; Veit Flockerzi; Nathan Dascal; U. Benjamin Kaupp; Franz Hofmann

doi:10.1016/0014-5793(93)80209-D

Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

Martin Biel, Wolfram Altenhofen, Roger Hullin, Jost Ludwig, Marc Freichel, Veit Flockerzi, Nathan Dascal, U. Benjamin Kaupp, Franz Hofmann^*

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

Original language	English
Pages (from-to)	134-138
Number of pages	5
Journal	FEBS Letters
Volume	329
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(93)80209-D
State	Published - 23 Aug 1993

Keywords

Aorta
Cyclic nucleotidegated channel
Expression
Primary structure

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10.1016/0014-5793(93)80209-D

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abstract = "Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.",

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AU - Biel, Martin

AU - Altenhofen, Wolfram

AU - Hullin, Roger

AU - Ludwig, Jost

AU - Freichel, Marc

AU - Flockerzi, Veit

AU - Dascal, Nathan

AU - Kaupp, U. Benjamin

AU - Hofmann, Franz

PY - 1993/8/23

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N2 - Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

AB - Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

KW - Aorta

KW - Cyclic nucleotidegated channel

KW - Expression

KW - Primary structure

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Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

Abstract

Keywords

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