Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

Martin Biel, Wolfram Altenhofen, Roger Hullin, Jost Ludwig, Marc Freichel, Veit Flockerzi, Nathan Dascal, U. Benjamin Kaupp, Franz Hofmann

Research output: Contribution to journalArticlepeer-review

Abstract

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.

Original languageEnglish
Pages (from-to)134-138
Number of pages5
JournalFEBS Letters
Volume329
Issue number1-2
DOIs
StatePublished - 23 Aug 1993

Keywords

  • Aorta
  • Cyclic nucleotidegated channel
  • Expression
  • Primary structure

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