Primary Oral Malignancy Imitating Peri-Implantitis

Vadim Raiser, Immad Abu-El Naaj, Benjamin Shlomi, Dan M. Fliss, Ilana Kaplan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Purpose To describe new cases of primary malignancy arising around dental implants. Materials and Methods Three patients presented with asymptomatic lesions around longstanding dental implants that resembled peri-implantitis. One case was primary large B-cell lymphoma and the remaining cases were primary squamous cell carcinoma in patients with oral lichen planus. The literature was reviewed for cases mimicking peri-implantitis. Results Of 42 implant-associated malignancies reported from 2000 through 2014, 85.7% were squamous cell carcinoma (69% primary and 9.4% metastatic). Most patients presented with pre-existing risk factors for oral cancer. Lymphoma was not associated with dental implants. Conclusions Primary and metastatic malignancies can occur in peri-implant mucosa, often with clinical and radiographic features resembling peri-implantitis. Clinicians should have a high index of suspicion for changes in peri-implant mucosa in patients with existing risk factors; however, rare cases such as lymphoma might present outside this risk population. Histopathologic analysis should be included in the management of selected peri-implant lesions to avoid delayed diagnosis of malignancy.

Original languageEnglish
Pages (from-to)1383-1390
Number of pages8
JournalJournal of Oral and Maxillofacial Surgery
Issue number7
StatePublished - 1 Jul 2016


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