Primary intraspinal primitive neuroectodermal tumor treated with autologous stem cell transplantation: Case report and review of the literature

Amir Nutman, Sergey Postovsky*, Irina Zaidman, Ronit Elhasid, Euvgeni Vlodavsky, Yitshak Kreiss, Myriam Weyl Ben Arush

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The authors describe the case of a 19-year-old female patient with a primary primitive neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute urinary retention and back pain for 2 months. Magnetic resonance imaging revealed an intradural extramedullary tumor, 6.5 cm long, in the region of the conus medullaris. Histological examination disclosed a small round cell tumor with immunohistochemical characteristics of a peripheral PNET. Metastatic workup showed no evidence of an intracranial tumor or metastases outside the neuroaxis. The patient received multidisciplinary treatment, including surgical excision, irradiation of the entire cranio-spinal axis, and high-dose chemotherapy with autologous stem cell rescue. Presently, 24 months after diagnosis, the patient remains in complete remission.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalPediatric Hematology and Oncology
Volume24
Issue number1
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Autologous peripheral blood stem cell transplantation
  • High-dose chemotherapy
  • Intraspinal primitive neuroectodermal tumor
  • Multidisciplinary treatment

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