TY - JOUR
T1 - Primary intraspinal primitive neuroectodermal tumor treated with autologous stem cell transplantation
T2 - Case report and review of the literature
AU - Nutman, Amir
AU - Postovsky, Sergey
AU - Zaidman, Irina
AU - Elhasid, Ronit
AU - Vlodavsky, Euvgeni
AU - Kreiss, Yitshak
AU - Ben Arush, Myriam Weyl
PY - 2007/1/1
Y1 - 2007/1/1
N2 - The authors describe the case of a 19-year-old female patient with a primary primitive neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute urinary retention and back pain for 2 months. Magnetic resonance imaging revealed an intradural extramedullary tumor, 6.5 cm long, in the region of the conus medullaris. Histological examination disclosed a small round cell tumor with immunohistochemical characteristics of a peripheral PNET. Metastatic workup showed no evidence of an intracranial tumor or metastases outside the neuroaxis. The patient received multidisciplinary treatment, including surgical excision, irradiation of the entire cranio-spinal axis, and high-dose chemotherapy with autologous stem cell rescue. Presently, 24 months after diagnosis, the patient remains in complete remission.
AB - The authors describe the case of a 19-year-old female patient with a primary primitive neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute urinary retention and back pain for 2 months. Magnetic resonance imaging revealed an intradural extramedullary tumor, 6.5 cm long, in the region of the conus medullaris. Histological examination disclosed a small round cell tumor with immunohistochemical characteristics of a peripheral PNET. Metastatic workup showed no evidence of an intracranial tumor or metastases outside the neuroaxis. The patient received multidisciplinary treatment, including surgical excision, irradiation of the entire cranio-spinal axis, and high-dose chemotherapy with autologous stem cell rescue. Presently, 24 months after diagnosis, the patient remains in complete remission.
KW - Autologous peripheral blood stem cell transplantation
KW - High-dose chemotherapy
KW - Intraspinal primitive neuroectodermal tumor
KW - Multidisciplinary treatment
UR - http://www.scopus.com/inward/record.url?scp=33845262828&partnerID=8YFLogxK
U2 - 10.1080/08880010601001396
DO - 10.1080/08880010601001396
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C2 - 17130114
AN - SCOPUS:33845262828
SN - 0888-0018
VL - 24
SP - 53
EP - 61
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 1
ER -
