Primary brain T-cell lymphoma in an HTLV-1 serologically positive male

Itay Lotan, Alexander Khlebtovsky, Edna Inbar, Julia Strenov, Ruth Djaldetti, Israel Steiner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Primary central nervous system lymphoma (PCNSL) is a subgroup of extranodal non-Hodgkin lymphoma usually due to B-cells. The incidence of T-cell PCNSL is 1-4% in Western countries. Human T-lymphotropic virus (HTLV-1) causes tropical spastic paraparesis/myelopathy and adult T-cell leukemia/lymphoma. We describe the extremely rare occurrence of T-cell PCNSL in a 29 year old HTLV-1 carrier. Additional unusual features of the case included the patient's young age and normal cerebrospinal fluid cytological findings, without leptomeningeal spread. Given the long latency between HTLV-1 infection and disease manifestation, more such cases may be diagnosed in the future. We recommend that every patient with T-cell PCNSL be screened for HTLV-1.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - 15 Mar 2012


FundersFunder number
Israeli Ministry of Health Chief Scientist
F. Hoffmann-La Roche
Israel Science Foundation


    • Brain tumor
    • Dementia
    • HTLV-1
    • Primary CNS lymphoma


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