TY - JOUR
T1 - Primary antiphospholipid syndrome with and without limb ischemia
T2 - A retrospective observational study
AU - de Carvalho, Jozélio Freire
AU - Brandão Neto, Rodrigo A.
AU - Skare, Thelma Larocca
AU - Shoenfeld, Yehuda
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/11
Y1 - 2023/11
N2 - Objective: To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI). Methods: A transverse study with 66 (83.3% female) PAPS patients was performed. All data were evaluated. Patients were subdivided into one of two groups: PAPS with LI and PAPS without LI and compared. Results: Sixty-six primary APS were selected. PAPS with LI group exhibited a longer disease duration (p =.012) and more arterial events (p =.002). A lower frequency of venous events was observed in PAPS with LI (p =.007), and deep venous thrombosis (p =.016). Furthermore, PAPS with LI patients had more deficiency of protein C of coagulation (p =.015) than the others. Conclusion: PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.
AB - Objective: To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI). Methods: A transverse study with 66 (83.3% female) PAPS patients was performed. All data were evaluated. Patients were subdivided into one of two groups: PAPS with LI and PAPS without LI and compared. Results: Sixty-six primary APS were selected. PAPS with LI group exhibited a longer disease duration (p =.012) and more arterial events (p =.002). A lower frequency of venous events was observed in PAPS with LI (p =.007), and deep venous thrombosis (p =.016). Furthermore, PAPS with LI patients had more deficiency of protein C of coagulation (p =.015) than the others. Conclusion: PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.
KW - Antiphospholipid syndrome
KW - antiphospholipid antibodies
KW - arterial thrombosis
KW - ischemic limb
KW - thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85174546650&partnerID=8YFLogxK
U2 - 10.1177/09612033231208347
DO - 10.1177/09612033231208347
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C2 - 37852301
AN - SCOPUS:85174546650
SN - 0961-2033
VL - 32
SP - 1486
EP - 1492
JO - Lupus
JF - Lupus
IS - 13
ER -