Primary anetoderma associated with a wide spectrum of autoimmune abnormalities

Emmilia Hodak*, Orna Shamai-Lubovitz, Michael David, Bilha Hazaz, Meir Lahav, Miriam Sandbank

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Although the underlying pathologic mechanisms of primary anetoderma have not yet been identified, data suggest the participation of an immunologic mechanism in some cases. In a woman with clinical and histopathologic features of primary anetoderma (Jadassohn-Pellizzari type) of 30 years' duration, laboratory investigation disclosed positive antinuclear factor, hypocomplementemia, hypergammaglobulinemia, granular deposits of immunoreactants along the dermoepidermal junction, and fibrillar deposits in the papillary dermis. In addition, she was found to have autoimmune hemolysis and circulating lupus anticoagulant associated with recurrent deep-vein thrombosis and a history of Graves' disease (starting 5 years after onset of primary anetoderma). To our knowledge, none of the latter three autoimmune conditions has been previously associated with primary anetoderma.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume25
Issue number2
DOIs
StatePublished - 1991

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