TY - JOUR
T1 - Prevention of recurrent aphthous stomatitis with colchicine
T2 - An open trial
AU - Katz, Joseph
AU - Shemer, Joshua
AU - Livneh, Avi
PY - 1994
Y1 - 1994
N2 - Background: Recurrent aphthous stomatitis (RAS) is a common disorder with hitherto unsatisfactory drug therapy. Objective: Our purpose was to evaluate the prophylactic effect of colchicine in the treatment of RAS. Methods: An open, prospective, 4-month study was conducted in 20 patients with RAS who served as their own controls. During the first 2 months of the study no medications were given and in the last 2 months colchicine, 1.5 mg/day, was prescribed. Results: The mean number of aphthae per week and the subjective daily pain scores were reduced by 71% and 77%, respectively, during colchicine treatment as compared with the previous period (p < 0.001 for both). No serious side effects of colchicine were noted. Conclusion: These findings suggest a role for continuous colchicine therapy in the prevention of RAS.
AB - Background: Recurrent aphthous stomatitis (RAS) is a common disorder with hitherto unsatisfactory drug therapy. Objective: Our purpose was to evaluate the prophylactic effect of colchicine in the treatment of RAS. Methods: An open, prospective, 4-month study was conducted in 20 patients with RAS who served as their own controls. During the first 2 months of the study no medications were given and in the last 2 months colchicine, 1.5 mg/day, was prescribed. Results: The mean number of aphthae per week and the subjective daily pain scores were reduced by 71% and 77%, respectively, during colchicine treatment as compared with the previous period (p < 0.001 for both). No serious side effects of colchicine were noted. Conclusion: These findings suggest a role for continuous colchicine therapy in the prevention of RAS.
UR - http://www.scopus.com/inward/record.url?scp=0028122336&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(94)70211-X
DO - 10.1016/S0190-9622(94)70211-X
M3 - מאמר
AN - SCOPUS:0028122336
VL - 31
SP - 459
EP - 461
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 3
ER -