Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Alaa Atamna; Dafna Yahav; Cédric Hirzel

doi:10.3389/ti.2023.11856

Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Alaa Atamna^*
, Dafna Yahav
, Cédric Hirzel

^*Corresponding author for this work

Internal Medicine

Rabin Medical Center Israel
Sheba Medical Center at Tel Hashomer
University of Bern

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

Original language	English
Article number	11856
Journal	Transplant International
Volume	36
DOIs	https://doi.org/10.3389/ti.2023.11856
State	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epstein-Barr virus
Kaposi sarcoma
human herpes virus 8
multicentic Castleman disease
posttransplant lymphoproliferative disorders
primary effusion lymphoma

Access to Document

10.3389/ti.2023.11856

Cite this

@article{eccb71bd6eee48cb9d5ae45ec4920614,

title = "Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients",

abstract = "Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients{\textemdash}EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.",

keywords = "Epstein-Barr virus, Kaposi sarcoma, human herpes virus 8, multicentic Castleman disease, posttransplant lymphoproliferative disorders, primary effusion lymphoma",

author = "Alaa Atamna and Dafna Yahav and C{\'e}dric Hirzel",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Atamna, Yahav and Hirzel.",

year = "2023",

doi = "10.3389/ti.2023.11856",

language = "אנגלית",

volume = "36",

journal = "Transplant International",

issn = "0934-0874",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

AU - Atamna, Alaa

AU - Yahav, Dafna

AU - Hirzel, Cédric

PY - 2023

Y1 - 2023

N2 - Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

AB - Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

KW - Epstein-Barr virus

KW - Kaposi sarcoma

KW - human herpes virus 8

KW - multicentic Castleman disease

KW - posttransplant lymphoproliferative disorders

KW - primary effusion lymphoma

UR - https://www.scopus.com/pages/publications/85178216111

U2 - 10.3389/ti.2023.11856

DO - 10.3389/ti.2023.11856

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 38046068

AN - SCOPUS:85178216111

SN - 0934-0874

VL - 36

JO - Transplant International

JF - Transplant International

M1 - 11856

ER -

Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this