Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Alaa Atamna; Dafna Yahav; Cédric Hirzel

doi:10.3389/ti.2023.11856

Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Alaa Atamna^*, Dafna Yahav, Cédric Hirzel

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

Original language	English
Article number	11856
Journal	Transplant International
Volume	36
DOIs	https://doi.org/10.3389/ti.2023.11856
State	Published - 2023

Keywords

Epstein-Barr virus
Kaposi sarcoma
human herpes virus 8
multicentic Castleman disease
posttransplant lymphoproliferative disorders
primary effusion lymphoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/ti.2023.11856

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title = "Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients",

abstract = "Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.",

keywords = "Epstein-Barr virus, Kaposi sarcoma, human herpes virus 8, multicentic Castleman disease, posttransplant lymphoproliferative disorders, primary effusion lymphoma",

author = "Alaa Atamna and Dafna Yahav and C{\'e}dric Hirzel",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Atamna, Yahav and Hirzel.",

year = "2023",

doi = "10.3389/ti.2023.11856",

language = "אנגלית",

volume = "36",

journal = "Transplant International",

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AB - Long-term risk for malignancy is higher among solid organ transplant (SOT) recipients compared to the general population. Four non-hepatitis viruses have been recognized as oncogenic in SOT recipients—EBV, cause of EBV-associated lymphoproliferative diseases; human herpes virus 8 (HHV8), cause of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease; human papilloma virus, cause of squamous cell skin cancers, and Merkel cell polyomavirus, cause of Merkel cell carcinoma. Two of these viruses (EBV and HHV8) belong to the human herpes virus family. In this review, we will discuss key aspects regarding the clinical presentation, diagnosis, treatment, and prevention of diseases in SOT recipients associated with the two herpesviruses.

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KW - Kaposi sarcoma

KW - human herpes virus 8

KW - multicentic Castleman disease

KW - posttransplant lymphoproliferative disorders

KW - primary effusion lymphoma

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Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients

Abstract

Keywords

UN SDGs

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