Prevention of dopaminergic toxicity of MPTP in mice by phenylethylamine, a specific substrate of type B monoamine oxidase

E. Melamed, M. B.H. Youdim

Research output: Contribution to journalArticlepeer-review

Abstract

N‐methyl‐4‐phenyl‐1, 2, 5, 6‐tetrahydropyridine (MPTP) is toxic to dopaminergic neurones in several mammalian species including mice. Combined treatment with phenylethylamine prevented in mice the long‐term (30 days post‐treatment) dopamine depletions in striatum induced by MPTP. Phenylethylamine, a naturally‐occuring specific substrate of monoamine oxidase (MAO) type B, probably protects against effects of MPTP by competitively inhibiting the oxidative conversion of MPTP to its toxic metabolite N‐methyl‐4‐phenylpyridinium ion catalysed by MAO‐B. 1985 British Pharmacological Society

Original languageEnglish
Pages (from-to)529-531
Number of pages3
JournalBritish Journal of Pharmacology
Volume86
Issue number3
DOIs
StatePublished - Nov 1985
Externally publishedYes

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