Prevention of colonization of the urinary tract of mice with escherichia coli by blocking of bacterial adherence with methyl a-d-mannopyranoside

M. Aronson*, O. Medalia, L. Schori, D. Mirelman, N. Sharon, I. Ofek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Methyl a-D-mannopyranoside (uMM), a competitor inhibitor of the binding of mannose by Escherichia coli, was tested for its ability to prevent infection of the urinary tract of mice with infective strains of the organisms. Injection of the bacteria in the presence of the drug resulted in a considerable reduction in the number of bacteriuric mice. In this system «MM was inactive against Proteus mirabilis in accordance with its inability to inhibit the adherence of this organism to epithelial cells in vitro, and methyl a-D-glucopyranoside proved inactive against both E. coli and P. mirabilis.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalJournal of Infectious Diseases
Volume139
Issue number3
DOIs
StatePublished - Mar 1979

Funding

FundersFunder number
United States-Israel Binational Science Foundation

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