TY - JOUR
T1 - Prevention of chemotherapy-induced ovarian damage
AU - Roness, Hadassa
AU - Kashi, Oren
AU - Meirow, Dror
PY - 2016
Y1 - 2016
N2 - Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity.
AB - Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity.
KW - Fertility preservation
KW - chemotherapy
KW - follicle activation
UR - http://www.scopus.com/inward/record.url?scp=84961927526&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2015.11.043
DO - 10.1016/j.fertnstert.2015.11.043
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C2 - 26677788
AN - SCOPUS:84961927526
SN - 0015-0282
VL - 105
SP - 20
EP - 29
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -