Prevention of chemotherapy-induced ovarian damage

Hadassa Roness, Oren Kashi, Dror Meirow

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity.

Original languageEnglish
Pages (from-to)20-29
Number of pages10
JournalFertility and Sterility
Volume105
Issue number1
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Fertility preservation
  • chemotherapy
  • follicle activation

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