Prevalence of Right Ventricle Strain Changes following Anthracycline Therapy

Michal Laufer-Perl*, Moran Perelman-Gvili*, Svetlana Sirota Dorfman, Guy Baruch, Ehud Rothschild, Gil Beer, Yaron Arbel, Joshua H. Arnold, Zach Rozenbaum, Shmuel Banai, Yan Topilsky, Livia Kapusta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Anthracycline (ANT) is the most recognized therapy known to cause cardi-otoxicity, mainly left ventricle (LV) dysfunction. Global Longitudinal Strain (GLS) is the optimal tool for assessment of subclinical LV dysfunction. Right ventricle (RV) function has been recognized as an independent factor for cardiac outcomes; however, data evaluating RV GLS is limited. We aimed to evaluate the change in RV GLS following ANT therapy. Methods: The study cohort is part of the Israel Cardio-Oncology Registry (ICOR). All patients performed echocardiography before (T1) and at the end (T3) of ANT therapy. A significant reduction was defined as a relative reduction of ≥ 10% in RV GLS values. Results: The study included 40 female patients with breast cancer treated with ANT. During follow-up, both RV GLS and free wall longitudinal strain systolic peak (RV FWLS PK) decreased significantly (p < 0.001 and p = 0.002). Altogether, 30 (75%) and 23 (58%) patients showed RV GLS and RV FWLS PK ≥ 10% relative reduction. At T3, LV ejection fraction and LV GLS were within normal range. Conclusions: RV GLS and RV FWLS PK reduction following ANT exposure is extremely frequent, comparing to LV GLS reduction.

Original languageEnglish
Article number291
Issue number2
StatePublished - Feb 2022


FundersFunder number
Israel Cardio-Oncology Registry
Pfizer pharmaceuticals Israel Ltd
Pfizer pharmaceuticals Israel Ltd.


    • Anthracycline
    • Cardio-oncology
    • Cardiotoxicity
    • Right ventricle
    • Strain


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