Prevalence of melanocytic nevi and freckles in young Israeli males: Correlation with melanoma incidence in Jewish migrants: Demographic and host factors

F. Pavlotsky, E. Azizi, R. Gurvich, A. Lusky, V. Barell, M. Weiner, J. Iscovich

Research output: Contribution to journalArticlepeer-review

Abstract

The role of host and environmental factors in the pathogenesis of multiple melanocytic nevi, atypical nevi, and freckles was studied in 1989 in a random sample of 3,040 Israeli males aged 17 years. Multiple melanocytic nevi were significantly associated with family history of melanoma or multiple melanocytic nevi (odds ratio (OR) = 15.0), fair or lightly pigmented skin color (OR = 2.7 and 2.3, respectively), and affiliation to the high or heterogenous melanoma risk group, determined by the incidence rates of melanoma in Jewish migrants from corresponding origin (OR = 3.1 and 2.1, respectively). An environment-related effect may account for the increased multiple melanocytic nevi risk among second- (OR = 8.2) compared with first- generation, native-born recruits (OR = 3.0) from the high melanoma risk group whose families had been living in Israel the longest. Atypical nevi were associated with fair (OR = 6.1) and lightly pigmented (OR = 3.5) skin color, high and moderate sunburn susceptibility (OR = 4.7 and 2.5, respectively), and family history of melanoma or multiple melanocytic nevi (OR = 4.7). Freckles were significantly associated with sun-sensitive phenotype, family history of melanoma or multiple melanocytic nevi (OR = 1.5), Conservative (OR = 1.9) or nonreligious status (OR = 1.9), and high (OR = 2.4) or heterogenous melanoma risk groups (OR = 1.8). These findings indicate that environmental factors may modify the occurrence of multiple melanocytic nevi and freckles in genetically susceptible ethnic groups.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalAmerican Journal of Epidemiology
Volume146
Issue number1
DOIs
StatePublished - 1 Jul 1997

Keywords

  • Freckles
  • Generation effect
  • Melanoma
  • Nevus
  • Skin pigmentation
  • Sunbathing
  • Transients and migrants

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