Prevalence of choroidal nevus and retinal pigment epithelial alterations in vitiligo patients

Efrat Fleissig*, Mor Pavlovksy, Anat Loewenstein, Dinah Zur, Hadas Newman, Shay Keren, Dafna Goldenberg, Efrat Bar-Ilan, Michaella Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF). Methods: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Statistical analysis was performed using paired T test and Pearson correlation. Results: A total of 61 eyes of 31 vitiligo patients were examined. Ocular findings consisted of choroidal nevi (n = 10, 32%), of which four (40%) were bilateral; two patients (6.5%) had a prominent choroidal pattern, two (6.5%) had hypopigmentary retinal pigment epithelium (RPE) lesions, and one (3.2%) had peripapillary atrophy of the RPE. Choroidal nevi were demonstrated only in eyes of patients with generalized vitiligo and were more common with upper body involvement (p = 0.02) and more prevalent in women (p = 0.02). Hypopigmentary lesions were detected in two patients and demonstrated on OCT as RPE atrophy and as photoreceptor/RPE changes. Conclusions: In this case series, vitiligo patients had a higher rate of choroidal nevi than previously reported. The hypopigmentary vitiliginous fundus lesions were depicted on OCT as photoreceptor and RPE atrophy. These findings may suggest the advisability of regular ocular monitoring for vitiligo patients.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
StatePublished - 1 May 2018


  • Choroidal nevus
  • Hypopigmentary lesion
  • RPE
  • Vitiligo


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