Prevalence of chlorpropamide alcohol flush in Jewish Israeli diabetics. The role of serum chlorpropamide concentrations

P. Segal, J. Brazu-Albu, S. Almog, M. Berezin

Research output: Contribution to journalArticlepeer-review

Abstract

Among 53 patients with noninsulin-dependent diabetes (NIDD), chlorpropamide alcohol flushing (CPAF) was more prevalent than among 18 patients with insulin-dependent diabetes (64 vs. 28%, respectively). Among the former, chronic users of chlorpropamide (CP) had a higher prevalence of CPAF than those challenged once with the drug (86 vs. 56%, respectively). Serum CP concentrations were much higher in CP-treated patients, but levels were not different in CPAF-positive compared with CPAF-negative subjects, regardless of the length of their exposure to the drug. Our data confirm the association between CPAF and NIDD in a Jewish Israeli diabetic population and the effect of serum CP levels and the prevalence of this phenomenon.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume21
Issue number2
StatePublished - 1985
Externally publishedYes

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