Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Y. Shoenfeld; I. Krause; F. Kvapil; J. Sulkes; S. Lev; P. Von Landenberg; J. Font; J. Zaech; R. Cervera; J. C. Piette; M. C. Boffa; M. A. Khamashta; M. L. Bertolaccini; G. R.V. Hughes; P. Youinou; P. L. Meroni; V. Pengo; J. D. Alves; A. Tincani; G. Szegedi; G. Lakos; G. Sturfelt; A. Jönsen; T. Koike; M. Sanmarco; A. Ruffatti; Z. Ulcova-Gallova; S. Praprotnik; B. Rozman; M. Lorber; V. B. Vriezman; M. Blank

doi:10.1023/A:1025321617304

Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Y. Shoenfeld^*, I. Krause, F. Kvapil, J. Sulkes, S. Lev, P. Von Landenberg, J. Font, J. Zaech, R. Cervera, J. C. Piette, M. C. Boffa, M. A. Khamashta, M. L. Bertolaccini, G. R.V. Hughes, P. Youinou, P. L. Meroni, V. Pengo, J. D. Alves, A. Tincani, G. SzegediG. Lakos, G. Sturfelt, A. Jönsen, T. Koike, M. Sanmarco, A. Ruffatti, Z. Ulcova-Gallova, S. Praprotnik, B. Rozman, M. Lorber, V. B. Vriezman, M. Blank

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six β2GPI-related peptides. A high degree of simultaneous reactivity against several β2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the β2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.

Original language	English
Pages (from-to)	377-383
Number of pages	7
Journal	Journal of Clinical Immunology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1023/A:1025321617304
State	Published - Sep 2003
Externally published	Yes

Keywords

Antiphospholipid syndrome
Autoimmunity
Synthetic peptides
Systemic lupus erythematosus

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10.1023/A:1025321617304

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Shoenfeld, Y., Krause, I., Kvapil, F., Sulkes, J., Lev, S., Von Landenberg, P., Font, J., Zaech, J., Cervera, R., Piette, J. C., Boffa, M. C., Khamashta, M. A., Bertolaccini, M. L., Hughes, G. R. V., Youinou, P., Meroni, P. L., Pengo, V., Alves, J. D., Tincani, A., ... Blank, M. (2003). Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome. Journal of Clinical Immunology, 23(5), 377-383. https://doi.org/10.1023/A:1025321617304

@article{b94d2fbd19584e1892db11ba1aecf519,

title = "Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome",

abstract = "Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six β2GPI-related peptides. A high degree of simultaneous reactivity against several β2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the β2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.",

keywords = "Antiphospholipid syndrome, Autoimmunity, Synthetic peptides, Systemic lupus erythematosus",

author = "Y. Shoenfeld and I. Krause and F. Kvapil and J. Sulkes and S. Lev and {Von Landenberg}, P. and J. Font and J. Zaech and R. Cervera and Piette, {J. C.} and Boffa, {M. C.} and Khamashta, {M. A.} and Bertolaccini, {M. L.} and Hughes, {G. R.V.} and P. Youinou and Meroni, {P. L.} and V. Pengo and Alves, {J. D.} and A. Tincani and G. Szegedi and G. Lakos and G. Sturfelt and A. J{\"o}nsen and T. Koike and M. Sanmarco and A. Ruffatti and Z. Ulcova-Gallova and S. Praprotnik and B. Rozman and M. Lorber and Vriezman, {V. B.} and M. Blank",

note = "Funding Information: This work was supported by a grant number 4706 given by The Chief Scientist—The Israeli Ministry of Health. This project was part of the EuroAPS forum.",

year = "2003",

month = sep,

doi = "10.1023/A:1025321617304",

language = "אנגלית",

volume = "23",

pages = "377--383",

journal = "Journal of Clinical Immunology",

issn = "0271-9142",

publisher = "Springer New York",

number = "5",

}

Shoenfeld, Y , Krause, I, Kvapil, F, Sulkes, J, Lev, S, Von Landenberg, P, Font, J, Zaech, J, Cervera, R, Piette, JC, Boffa, MC, Khamashta, MA, Bertolaccini, ML, Hughes, GRV, Youinou, P, Meroni, PL, Pengo, V, Alves, JD, Tincani, A, Szegedi, G, Lakos, G, Sturfelt, G, Jönsen, A, Koike, T, Sanmarco, M, Ruffatti, A, Ulcova-Gallova, Z, Praprotnik, S, Rozman, B, Lorber, M, Vriezman, VB & Blank, M 2003, 'Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome', Journal of Clinical Immunology, vol. 23, no. 5, pp. 377-383. https://doi.org/10.1023/A:1025321617304

TY - JOUR

T1 - Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome

AU - Shoenfeld, Y.

AU - Krause, I.

AU - Kvapil, F.

AU - Sulkes, J.

AU - Lev, S.

AU - Von Landenberg, P.

AU - Font, J.

AU - Zaech, J.

AU - Cervera, R.

AU - Piette, J. C.

AU - Boffa, M. C.

AU - Khamashta, M. A.

AU - Bertolaccini, M. L.

AU - Hughes, G. R.V.

AU - Youinou, P.

AU - Meroni, P. L.

AU - Pengo, V.

AU - Alves, J. D.

AU - Tincani, A.

AU - Szegedi, G.

AU - Lakos, G.

AU - Sturfelt, G.

AU - Jönsen, A.

AU - Koike, T.

AU - Sanmarco, M.

AU - Ruffatti, A.

AU - Ulcova-Gallova, Z.

AU - Praprotnik, S.

AU - Rozman, B.

AU - Lorber, M.

AU - Vriezman, V. B.

AU - Blank, M.

N1 - Funding Information: This work was supported by a grant number 4706 given by The Chief Scientist—The Israeli Ministry of Health. This project was part of the EuroAPS forum.

PY - 2003/9

Y1 - 2003/9

N2 - Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six β2GPI-related peptides. A high degree of simultaneous reactivity against several β2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the β2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.

AB - Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six β2GPI-related peptides. A high degree of simultaneous reactivity against several β2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the β2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.

KW - Antiphospholipid syndrome

KW - Autoimmunity

KW - Synthetic peptides

KW - Systemic lupus erythematosus

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DO - 10.1023/A:1025321617304

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AN - SCOPUS:0042832999

SN - 0271-9142

VL - 23

SP - 377

EP - 383

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 5

ER -

Prevalence and clinical correlations of antibodies against six β2-glycoprotein-I-related peptides in the antiphospholipid syndrome

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Keywords

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