Prevalence and Clinical Characteristics of Paraproteinemia Associated with Chronic Myeloid Leukemia

Tamar Berger*, Adi Shacham Abulafia, Shai Shimony, Oren Pasvolsky, Iuliana Vaxman, Yifat Miron, Shimrit Feldman, Avi Leader, Pia Raanani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: Data regarding the prevalence of paraproteinemia in patients with chronic myeloid leukemia (CML) are lacking. Methods: To evaluate for the prevalence of paraproteinemia, we undertook this cross-sectional study among consecutive chronic-phase CML patients. Complete blood count, chemistry, immunoglobulins, serum-free light chains, serum-protein electrophoresis and immunofixation were collected. Further analyses evaluated whether various patient-, disease-, and treatment-related variables are associated with paraproteinemia. Results: One hundred patients, median age 63.5 (IQR 48.1-72) years were recruited. Median time from CML diagnosis to enrollment was 6.3 (IQR 2.3-11.3) years. Monoclonal protein was detected in 8 patients (8%), diagnosed with smoldering multiple myeloma (SMM, n = 2) and low-risk monoclonal gammopathy of undetermined significance (MGUS, n = 6). Six patients were on tyrosine kinase inhibitor treatment, 2 were in treatment-free remission. The only covariate associated with paraproteinemia was the presence of anemia, albeit with borderline statistical significance in univariate analysis (p = 0.053) and when adjusted for age (p = 0.056). Conclusions: In this largest study so far describing the prevalence of paraproteinemia among CML patients, we found MGUS prevalence to be higher than the 3.2% expected prevalence in the general population above 50 years and a non-negligible prevalence of SMM (2%). Screening for paraproteinemia in CML patients, especially in the presence of anemia, should be considered.

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalActa Haematologica
Issue number6
StatePublished - 1 Nov 2022


  • Chronic myeloid leukemia
  • Monoclonal gammopathies
  • Multiple myeloma
  • Paraproteinemia
  • Smoldering multiple myeloma


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