TY - JOUR
T1 - Pressure effect on the nonradiative process of thioflavin-T
AU - Amdursky, Nadav
AU - Gepshtein, Rinat
AU - Erez, Yuval
AU - Koifman, Naum
AU - Huppert, Dan
PY - 2011/6/23
Y1 - 2011/6/23
N2 - Time-resolved emission techniques were employed to study the nonradiative process of thioflavin-T (ThT) in 1-propanol, 1-butanol, and 1-pentanol as a function of the hydrostatic pressure. Elevated hydrostatic pressure increases the alcohol viscosity, which in turn strongly influences the nonradiative rate of ThT. A diamond-anvil cell was used to increase the pressure up to 2.4 GPa. We found that the nonradiative rate constant, knr, decreases with pressure. We further found a remarkable linear correlation between a decrease in knr (increase in the nonradiative lifetime, Tnr) and an increase in the solvent viscosity. The viscosity was varied by a factor of 1000 and knr was measured at high pressures, at which the nonradiative rate constant of the molecules decreased from (7 ps)-1 to (13 ns)-1, (13 ps)-1 to (17 ns)-1 and (17 ps) -1 to (15 ns)-1 for 1-propanol, 1-butanol, and 1-pentanol, respectively. The viscosity-dependence of knr is explained by the excited-state rotation rate of the two-ring systems, with respect to each other.
AB - Time-resolved emission techniques were employed to study the nonradiative process of thioflavin-T (ThT) in 1-propanol, 1-butanol, and 1-pentanol as a function of the hydrostatic pressure. Elevated hydrostatic pressure increases the alcohol viscosity, which in turn strongly influences the nonradiative rate of ThT. A diamond-anvil cell was used to increase the pressure up to 2.4 GPa. We found that the nonradiative rate constant, knr, decreases with pressure. We further found a remarkable linear correlation between a decrease in knr (increase in the nonradiative lifetime, Tnr) and an increase in the solvent viscosity. The viscosity was varied by a factor of 1000 and knr was measured at high pressures, at which the nonradiative rate constant of the molecules decreased from (7 ps)-1 to (13 ns)-1, (13 ps)-1 to (17 ns)-1 and (17 ps) -1 to (15 ns)-1 for 1-propanol, 1-butanol, and 1-pentanol, respectively. The viscosity-dependence of knr is explained by the excited-state rotation rate of the two-ring systems, with respect to each other.
UR - http://www.scopus.com/inward/record.url?scp=79959210880&partnerID=8YFLogxK
U2 - 10.1021/jp201537k
DO - 10.1021/jp201537k
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AN - SCOPUS:79959210880
VL - 115
SP - 6481
EP - 6487
JO - Journal of Physical Chemistry A
JF - Journal of Physical Chemistry A
SN - 1089-5639
IS - 24
ER -