Presentation, natural history, and management of carotid cavernous aneurysms

Hadas Stiebel-Kalish, Yuval Kalish, Ruth Huna Bar-On, Avi Setton, Yasu Niimi, Alejandro Berenstein, Mark J. Kupersmith

Research output: Contribution to journalReview articlepeer-review


OBJECTIVE: We present the largest reported cohort of carotid cavernous aneurysms (CCA), comparing the neuro-ophthalmic presentation, complications, and outcome with and without endovascular treatment. METHODS: Retrospective review of 185 patients with 206 CCAs examined between 1980 and 2001 at a tertiary neuro-ophthalmology and neurovascular service. Patients' symptoms and findings at presentation were recorded and compared with those at outcome. The effect of treatment on outcome and on complication rate was analyzed using the χ2 test, multivariate analysis of covariance, model-selection log-linear analysis, and multinomial logistic regression. RESULTS: Long-term follow-up was available for 189 of 206 CCAs. Seventy-four CCAs underwent treatment (endovascular, 67 [91%]; surgical treatment, 6 [19%]), and 115 were followed for an average of 4 years, two of which required later treatment. Treatment reduced the incidence_and severity of pain, even after adjusting for the severity of initail pain. (F(1,192 = 9.59, P = 0.002). Treatment did not significantly affect the patient's final diplopia after adjusting for their initial diplopia (F(1, 182 = 2.01, P = 0.158). Statistical examination revealed that the treated group had a higher proportion of of neurological and visual complications than people who were not treated (2(2). = 25.26, P = 0.0003. CONCLUSION: Endovascular treatment of carotid cavernous aneurysms leads to a significantly higher rate of pain resolution compared with untreated patients, even after adjusting for initial pain severity. Diplopia may not resolve after treatment. The result of this study underscore our approach indicating treatment only in cases of debilitating pain, visual loss from compression, or diplopia in primary gaze or in patients with risk factors for major complications such as pre-existing coagulopathy or sphenoid sinus erosion.

Original languageEnglish
Pages (from-to)850-856
Number of pages7
Issue number5
StatePublished - Nov 2005
Externally publishedYes


  • Carotid cavernous
  • Diplopia
  • Endovascular
  • Pain


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